Fluid-Structure Interaction Assessment of Biomechanical Performances of Biohybrid Graft Implanted in Murine Models

Objective. One of the major failure causes of synthetic grafts is the compliance mismatch with the native vessels. We developed a computational pipeline to comprehensively assess the biomechanical performances of an innovative multilayers graft fabricated by our group. Methods. Two different surgical scenarios on murine models were simulated through FSI analysis, exploiting geometries and velocity data derived from 2D-echo. Results. Stress intensification with oscillatory features was observed at anastomoses. Low and oscillating shear stress were predicted in regions where intimal hyperplasia occurred in the in-vivo tests. Conclusion. Numerical approach could provide preliminary assessment of the fabricated graft: if further validated, it could play a crucial role in its design.