We carry out an in vivo validation of a new method for estimating blood flow rate from the maximum velocity, as it is usually done in single-wire Doppler catheter measurements. A common practice is to measure the centerline velocity and to recover the flow rate (a-priori approach) by exploiting an assumption on the shape of velocity profile, either a parabolic or a flat one. Our method proposes a new formula valid for the peak instant linking the maximum velocity and the flow rate including the Womersley number, in order to account in a more accurate way the haemodynamics conditions (Womersley-based approach). In vivo validation of the Womersley-based approach is performed. An experimental protocol using cine Phase Contrast MRI (2D PCMRI) technique has been designed and applied to ten healthy young volunteers in three different arterial districts: the abdominal aorta, the common carotid artery and the brachial artery. Each PCMRI dataset has been used twice. 1) To compute the value of the blood flow rate used as a gold standard. 2) To estimate the flow rate using information only on the maximum velocity and on the diameter value (i.e. emulating the intravascular Doppler data acquisition) by using the a priori and the Womersley-based approaches. All the in vivo results concerning the three arterial districts allow to state that the Womersley-based approach provides better estimates of the flow rate at the peak instant with the respect to the a-priori approach. These results might have relevant clinical implication, for example in Coronary Flow Reserve determination.

Ponzini, Raffaele, VERGARA, Christian, Rizzo, Giovanna, Veneziani, Alessandro, Redaelli, Alberto, Roghi, Alberto, Vanzulli, Angelo, Parodi, Oberdan, (2009). Computational fluid dynamics-based estimation of blood flow rate in Doppler analysis: in vivo validation by means of Phase Contrast Magnetic Resonance Imaging 6/MS (2009)). Bergamo: Retrieved from http://hdl.handle.net/10446/512

Computational fluid dynamics-based estimation of blood flow rate in Doppler analysis: in vivo validation by means of Phase Contrast Magnetic Resonance Imaging

VERGARA, Christian;
2009-01-01

Abstract

We carry out an in vivo validation of a new method for estimating blood flow rate from the maximum velocity, as it is usually done in single-wire Doppler catheter measurements. A common practice is to measure the centerline velocity and to recover the flow rate (a-priori approach) by exploiting an assumption on the shape of velocity profile, either a parabolic or a flat one. Our method proposes a new formula valid for the peak instant linking the maximum velocity and the flow rate including the Womersley number, in order to account in a more accurate way the haemodynamics conditions (Womersley-based approach). In vivo validation of the Womersley-based approach is performed. An experimental protocol using cine Phase Contrast MRI (2D PCMRI) technique has been designed and applied to ten healthy young volunteers in three different arterial districts: the abdominal aorta, the common carotid artery and the brachial artery. Each PCMRI dataset has been used twice. 1) To compute the value of the blood flow rate used as a gold standard. 2) To estimate the flow rate using information only on the maximum velocity and on the diameter value (i.e. emulating the intravascular Doppler data acquisition) by using the a priori and the Womersley-based approaches. All the in vivo results concerning the three arterial districts allow to state that the Womersley-based approach provides better estimates of the flow rate at the peak instant with the respect to the a-priori approach. These results might have relevant clinical implication, for example in Coronary Flow Reserve determination.
2009
Ponzini, Raffaele; Vergara, Christian; Rizzo, Giovanna; Veneziani, Alessandro; Redaelli, Alberto; Roghi, Alberto; Vanzulli, Angelo; Parodi, Oberdan...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10446/512
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