The title compound, C16H12N2O3, is a novel potent and selective non-competitive antagonist at AMPA/kainate receptors [AMPA is 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid and kainate is 3-carboxymethyl-4-iso-propenylpyrrolidine-2-carboxylic acid]. The crystal structure has been determined at room temperature by X-ray diffraction and the seven-membered ring shows the usual boat conformation. The energy stabilization of the crystal packing of the title compound by significant hydrogen-bond interactions is discussed using theoretical computations.
(2003). 5-Phenyl-9H-1,3-dioxolo[4,5-h] [2,3]benzodiazepin-8 (7H)-one [journal article - articolo]. In ACTA CRYSTALLOGRAPHICA. SECTION C, CRYSTAL STRUCTURE COMMUNICATIONS. Retrieved from http://hdl.handle.net/10446/166209
5-Phenyl-9H-1,3-dioxolo[4,5-h] [2,3]benzodiazepin-8 (7H)-one
Rosace, G.
2003-01-01
Abstract
The title compound, C16H12N2O3, is a novel potent and selective non-competitive antagonist at AMPA/kainate receptors [AMPA is 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid and kainate is 3-carboxymethyl-4-iso-propenylpyrrolidine-2-carboxylic acid]. The crystal structure has been determined at room temperature by X-ray diffraction and the seven-membered ring shows the usual boat conformation. The energy stabilization of the crystal packing of the title compound by significant hydrogen-bond interactions is discussed using theoretical computations.| File | Dimensione del file | Formato | |
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