Background: Cancer patients present with a hypercoagulable state often associated with poor disease prognosis. Objectives: This study aims to evaluate whether thrombin generation (TG), a global coagulation test, may be a useful tool to improve the identification of patients at high risk of early disease recurrence (ie, E-DR within 2 years) after breast cancer surgery. Patients/Methods: A cohort of 522 newly diagnosed patients with surgically resected high-risk breast cancer were enrolled in the ongoing prospective HYPERCAN study. TG potential was measured in plasma samples collected before starting systemic chemotherapy. Significant predictive hemostatic and clinic-pathological parameters were identified in the derivation cohort by Cox regression analysis. A risk prognostic score for E-DR was generated in the derivation and tested in the validation cohort. Results: After a median observation period of 3.4 years, DR occurred in 51 patients, 28 of whom were E-DR. E-DR subjects presented with the highest TG values as compared to both late-DR (from 2 to 5 years) and no relapse subjects (P <.01). Multivariate analysis in the derivation cohort identified TG, mastectomy, triple negative and Luminal B HER2-neg molecular subtypes as significant independent predictors for E-DR, which were utilized to generate a risk assessment score. In the derivation and validation cohorts, E-DR rates were 2.3% and 0% in the low-risk, 10.1% and 6.3% in the intermediate-risk, and 18.2% and 16.7%, in the high-risk categories, respectively. Conclusions: Inclusion of TG in a risk-assessment model for E-DR significantly helps the identification of operated breast cancer patients at high risk of very early relapse.

(2020). Thrombin generation predicts early recurrence in breast cancer patients [journal article - articolo]. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Retrieved from http://hdl.handle.net/10446/175591

Thrombin generation predicts early recurrence in breast cancer patients

Malighetti, Paolo;
2020

Abstract

Background: Cancer patients present with a hypercoagulable state often associated with poor disease prognosis. Objectives: This study aims to evaluate whether thrombin generation (TG), a global coagulation test, may be a useful tool to improve the identification of patients at high risk of early disease recurrence (ie, E-DR within 2 years) after breast cancer surgery. Patients/Methods: A cohort of 522 newly diagnosed patients with surgically resected high-risk breast cancer were enrolled in the ongoing prospective HYPERCAN study. TG potential was measured in plasma samples collected before starting systemic chemotherapy. Significant predictive hemostatic and clinic-pathological parameters were identified in the derivation cohort by Cox regression analysis. A risk prognostic score for E-DR was generated in the derivation and tested in the validation cohort. Results: After a median observation period of 3.4 years, DR occurred in 51 patients, 28 of whom were E-DR. E-DR subjects presented with the highest TG values as compared to both late-DR (from 2 to 5 years) and no relapse subjects (P <.01). Multivariate analysis in the derivation cohort identified TG, mastectomy, triple negative and Luminal B HER2-neg molecular subtypes as significant independent predictors for E-DR, which were utilized to generate a risk assessment score. In the derivation and validation cohorts, E-DR rates were 2.3% and 0% in the low-risk, 10.1% and 6.3% in the intermediate-risk, and 18.2% and 16.7%, in the high-risk categories, respectively. Conclusions: Inclusion of TG in a risk-assessment model for E-DR significantly helps the identification of operated breast cancer patients at high risk of very early relapse.
articolo
Marchetti, Marina; Giaccherini, Cinzia; Masci, Giovanna; Verzeroli, Cristina; Russo, Laura; Celio, Luigi; Sarmiento, Roberta; Gamba, Sara; Tartari, Carmen J.; Diani, Erika; Vignoli, Alfonso; Malighetti, Paolo; Spinelli, Daniele; Kuderer, Nicole M.; Nichetti, Federico; Minelli, Mauro; Tondini, Carlo; Barni, Sandro; Giuliani, Francesco; Petrelli, Fausto; D'Alessio, Andrea; Gasparini, Gianpietro; Labianca, Roberto; Santoro, Armando; De Braud, Filippo; Falanga, Anna
(2020). Thrombin generation predicts early recurrence in breast cancer patients [journal article - articolo]. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Retrieved from http://hdl.handle.net/10446/175591
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10446/175591
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