Group 2 Pulmonary Hypertension: Clinical Features and Treatment

Pulmonary hypertension (PH) is frequent in left heart disease (LHD), especially in heart failure with preserved ejection fraction (HFpEF). In contrast with group 1 PH, PH due to HFpEF is triggered by the underlying condition through a passive increase in left atrial pressure. A small subset of patients may present pulmonary vascular disease, which has a greater impact on exercise capacity, outcome and represents a diagnostic challenge. This chapter highlights the importance of properly phenotyping group 2 PH patients and the lack of evidence supporting the use of specific therapies for this condition.